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KMID : 0043319930160030237
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Archives of Pharmacal Research
1993 Volume.16 No. 3 p.237 ~ p.243
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Effects of Ginseng Total Saponins on the Antinociception and the Tolerance Development of U-50,488H
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Kim Hack-Seang
Kim Sun-Hye
Seong Yeon-Hee
Oh Ki-Wan
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Abstract
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These studies were performed to investigate the acting sites of ginseng total saponins (GTS) on the U-50, 488H-induced antinociception and the inhibitory effect of the development of tolerance to U-50, 488H-induced antinociception by GTS were studied. The U-50, 488H-induced antinociception was ntagonized in mice pretreated with GTS intraperitoneally, intracerebrally. These antagonisms were reversed by the pretratment iwth a serotonin precursor, 5-hydroxytrypophan (5-HTP), but not with a noradrenaline precursor, L-dihydroxyphenylalanine (L-DOPA). However, the intraplantar sites. On the other hand, GTS inhibited the development of tolerance to U-50, 488H-induced antinociception was reversed by pretreatment with 5-HTP, but not with L-DOPA. Therefore, the antagonism of U-50, 488H-induced antinociception and the inhibition of the development of tolerance to U-50, 488H-induced antinociception and the inhibition of the development of tolerance to U-50, 488H-induced antinociception by GTS are dependent on serotonegic mechanisms.
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KEYWORD
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U-50, 488H-induced antinociception, Antagonism, Tolerance, Ginseng total saponins(GTS), Serotonergic mechanisms
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